Boston Scientific
Corporation (NYSE: BSX) announced the schedule of the Company's major
events and press announcements at the Cardiovascular Research Foundation's
(CRF) twentieth annual Transcatheter Cardiovascular Therapeutics (TCT)
scientific symposium, which runs from October 12 to 17 in Washington, D.C.
Boston Scientific will be announcing a wide range of safety and
efficacy data on its TAXUS(R) Express2(TM) and second-generation TAXUS(R)
Liberte(R) Paclitaxel-Eluting Coronary Stent Systems, including 12-month
subset data on patients with left main (LM) and three-vessel disease (3VD)
from the SYNTAX trial, which compares percutaneous coronary intervention
(PCI) using the TAXUS Express2 Stent System to coronary artery bypass graft
(CABG) surgery in these most complex patient groups. In addition, the
Company will present two-year results from the ARRIVE diabetic subset
analysis (TAXUS Express Stent), three-year data from the ATLAS Workhorse
and Direct Stenting trials and two-year ATLAS data on small vessels and
long lesions (TAXUS Liberte Stent).
"We are pleased to be announcing new subset data on left main and
three-vessel disease patients from the landmark SYNTAX study, the only
randomized trial of its kind to provide physicians with critical data on
the performance of drug-eluting stents (DES) in these very difficult
patient populations," said Keith D. Dawkins, M.D., Senior Vice President
and Associate Chief Medical Officer at Boston Scientific. "We also plan to
present additional detail on the SYNTAX Score -- a new scientific measure
for anatomical complexity designed to provide guidance to physicians is
assessing treatment options for LM and 3VD patients."
Schedule of Events
Sunday, October 12 (all times are ET)
-- TAXUS ATLAS Workhorse, Direct Stenting, Small Vessel and Long Lesion
studies. Three-year data from the TAXUS ATLAS Workhorse study and two-year
data from the TAXUS ATLAS Direct Stent study will be presented by the
study's co-principal investigator Mark A. Turco, M.D., in an e-poster
session titled "TAXUS ATLAS and TAXUS ATLAS DIRECT STENT Trials: Durable
Effectiveness of the TAXUS Liberte Stent and Long-Term Benefit of Direct
Stenting". In addition, two-year data from the TAXUS ATLAS Small Vessel and
Long Lesion studies will be presented by John A. Ormiston, M.D., in an
e-poster session titled "Durable Benefit of TAXUS Liberte vs. TAXUS Express
in Small Vessels and Long Lesions in the TAXUS ATLAS SMALL VESSEL and TAXUS
ATLAS LONG LESION Trials". TAXUS ATLAS is a global, multi-center,
single-arm study designed to demonstrate that the TAXUS Liberte Stent is
non-inferior in safety and efficacy to the TAXUS Express Stent. The Company
plans to issue a press release at this time.
-- TAXUS ARRIVE diabetic data. A diabetic sub-group analysis from the
TAXUS ARRIVE registry will be presented by John M. Lasala, M.D., PhD, in an
e-poster session titled "TAXUS Mitigates the Effect of Diabetes on
Restenosis Independent of Patient Risk Profile: Two-Year Results from the
TAXUS ARRIVE Program". The ARRIVE program is designed to collect and
analyze "real-world" safety and clinical outcomes data from the TAXUS
Express2 Paclitaxel-Eluting Coronary Stent System in the treatment of
patients with coronary artery disease. The Company plans to issue a press
release at this time.
Tuesday, October 14
-- SYNTAX Study subset data. The latest 12-month outcomes subset data
from the SYNTAX trial will be presented by Principal Investigators Patrick
W. Serruys, M.D., Ph.D., and Friedrich W. Mohr, M.D., beginning at 11:10
a.m. in the Main Arena of the Washington Convention Center. Dr. Serruys
will present a Featured Lecture on "Revascularization in Patients with
Unprotected Left Main Coronary Artery Disease," while Dr. Mohr will present
on "Revascularization in Patients with Triple Vessel Coronary Artery
Disease." SYNTAX is the first randomized, controlled clinical trial
comparing PCI using drug-eluting stents to CABG in patients with left main
and/or three-vessel disease. The Company plans to issue a press release at
this time. Dr. Serruys will present additional details on the SYNTAX Score
during his Featured Lecture as well as during Tuesday's Focus on SYNTAX
Sessions in a presentation titled "SYNTAX Score: Methodology and
Importance."
-- Focus on SYNTAX. From 2:00 -- 6:00 p.m., a series of focus sessions
titled "Revascularization for Left Main and Triple-Vessel Disease: Focus on
SYNTAX" will take place in Room 147AB. Details on the topics and presenters
can be found in the official TCT program.
-- Symposium on SYNTAX Trial Data. From 8:00 -- 10:00 p.m., the Company
will sponsor a symposium entitled "The SYNTAX Trial: Understanding the Data
in Complex Anatomies and Advanced Disease," chaired by Dr. Serruys in the
Grand Ballroom of the Renaissance Hotel. The symposium will offer an
overview of the latest SYNTAX trial data and feature a panel discussion on
subset case presentations for patients with multi-vessel disease and left
main disease. The symposium will include panel members Ted E. Feldman,
M.D., Michael J. Mack, M.D., Martin B. Leon, M.D., and Friedrich W. Mohr,
M.D. A reception will be held prior to the symposium at 7:00 p.m.
Wednesday, October 15
-- OLYMPIA High-Risk Subgroups. One-year results from Intercontinental
and European Launch Phases of the global OLYMPIA registry will be presented
in an oral abstract session by Waqar H. Ahmed, M.D., M.S., FACC, at 8:41
a.m., in Room 145AB. OLYMPIA is the world's largest prospective,
multi-center, multi-phased registry for a single drug-eluting stent. The
registry is designed to analyze real-world clinical outcomes data for
Boston Scientific's second-generation TAXUS Liberte Paclitaxel-Eluting
Coronary Stent System. Results from more than 22,000 patients will focus on
safety and efficacy, and will highlight outcomes within high-risk lesion
subgroups and patients with serious co-morbid conditions. The Company plans
to issue a press release at this time.
-- HORIZONS AMI data. At 11:00 a.m., Gregg W. Stone, M.D., will present
data from the featured trial of the day "HORIZONS AMI: A Prospective
Randomized Trial of Paclitaxel-Eluting Stents vs. Bare-Metal Stents in
Patients with Acute ST-Segment Elevation Myocardial Infarction" in the Main
Arena. The HORIZONS AMI trial is a randomized, controlled clinical trial
designed to compare TAXUS stents to bare-metal stents in 3,400 AMI (acute
myocardial infarction) patients. The Company plans to issue a press release
at this time.
-- SYNTAX Sessions. From 10:15 a.m. -- 12:30 p.m., an additional series
of sessions moderated by Dean J. Kereiakes, M.D., and Craig R. Smith, M.D.,
titled "Coronary Artery Disease I: Revascularization Controversies" will
occur in Room 206. Details on the topics and presenters can be found in the
official TCT program.
Boston Scientific will present its latest innovations at booth 814 on
Level 2 of the Exhibition Hall, including the TAXUS(R) Express2(TM)
Atom(TM) Paclitaxel-Eluting Coronary Stent System, which recently became
the only DES approved by the FDA for use in vessels as small as 2.25 mm in
diameter.
The safety and effectiveness of the TAXUS Express Stent has not been
established in patients with left main, three vessel disease, or an acute
MI. In the U.S., the TAXUS Liberte Stent is an investigational device and
is not available for sale.
Boston Scientific is a worldwide developer, manufacturer and marketer
of medical devices whose products are used in a broad range of
interventional medical specialties. For more information, please visit:
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Boston Scientific Corporation
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